Summary of "What is Pleomorphism? - Pathology mini tutorial"

Summary

The video discusses the concept of Pleomorphism in pathology, particularly in relation to tumors. Pleomorphism refers to the presence of various distinct forms within a tumor, leading to architectural diversity, and is often characterized by variations in the size and shape of cells and their nuclei.

Key Concepts

Pleomorphism: Variation in size and shape of cells and/or nuclei within tumors.
Pleomorphic Adenoma: A mixed tumor of the salivary gland showcasing architectural diversity with benign epithelial cells and mature benign cartilage.
Histological Diversity: Observed in pleomorphic adenomas, indicating the presence of different cell types within the tumor.
Cellular and Nuclear Pleomorphism:
- Can occur in both benign and malignant tumors.
- Example of benign tumor: Pleomorphic Lipoma, which has varied nuclei sizes and shapes.
- Example of malignant tumor: Pleomorphic Liposarcoma, characterized by extreme variation in cell and nucleus sizes and shapes.

Differences Between Terms

Pleomorphic vs. Anaplastic:
- Pleomorphic cells may be benign and not necessarily anaplastic (malignant).
- Anaplastic cells are often associated with high-grade, poorly differentiated malignant tumors.

Examples of Tumors

Pleomorphic Lipoma: A benign tumor exhibiting cellular and nuclear Pleomorphism.
Pleomorphic Liposarcoma: A malignant tumor noted for significant variation in cell and nucleus morphology.